Merkel Cell Polyomavirus–Positive Panniculitic Merkel Cell Carcinoma: A Rare Neoplasm of Unknown Histogenesis
نویسندگان
چکیده
منابع مشابه
Merkel Cell Polyomavirus: A Causal Factor in Merkel Cell Carcinoma
The RNA viruses hepatitis C virus and human T-cell lymphotropic virus type I (or human T-cell leukaemia virus type 1), and the DNA viruses hepatitis B virus, high-risk human papillomaviruses, human herpes virus-8 (Kaposi’s sarcoma-associated herpes virus) and Epstein Barr virus are acknowledged as carcinogenic to humans. Human polyomaviruses have oncogenic potentials in cell cultures and animal...
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conclusions the findings of this study are consistent with the hypothesis that local, systemic, or tumor-induced immunosuppression may allow the mcpyv to initiate skin aggressive cancer. it is necessary to maintain regular check over patients taking immunosuppressive medications for mcpyv infection. since there is not any information about detection and molecular biology analysis of mcpyv among...
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We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.
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Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread.
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Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine skin cancer of elderly patients. Generally, it originates from Merkel cells of the basal layer of the epidermis characterized by typical neuroendocrine granules (neuron-specific enolase; NSE+) and keratin filament (cytokeratin-20; CK20). Its incidence has been increasing in the last two decades, likely because of improved ability t...
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ژورنال
عنوان ژورنال: The American Journal of Dermatopathology
سال: 2020
ISSN: 0193-1091
DOI: 10.1097/dad.0000000000001404